Abstract

Cancer is among the leading causes of death worldwide, ranking as the third leading cause of mortality in Mexico. Despite the availability of several therapies aimed at reducing and attempting to eradicate this disease, such as chemotherapy, these treatments often present significant side effects that can debilitate patients due to their inability to differentiate between healthy and cancerous cells. Consequently, nanotechnology has emerged as a promising approach to address this issue, particularly using magnetic nanoparticles, especially those based on iron oxide. These nanoparticles exhibit superparamagnetic properties that allow for activation by an external magnetic field, making them particularly suitable for magnetic hyperthermia?a safer and more precise therapeutic strategy for cancer treatment. Additionally, metal-organic frameworks (MOFs) are being investigated for their unique combination of properties derived from both inorganic and organic nanoparticles, rendering them suitable for applications in adsorption, separation, storage, and drug delivery within therapeutic and biomedical contexts. This work proposes a core-shell system comprising a UiO-66 metal-organic framework coated on Fe3O4@L-cys nanoparticles, referred to as UiO-66/Fe3O4@L-cys, for use in magnetic hyperthermia. Various characterisation techniques such as FTIR, Raman spectroscopy, XRD, DLS, SEM/EDX, TGA, and BET demonstrate the successful synthesis of Fe3O4@L-cys and its capacity to increase temperature through magnetic hyperthermia assays. However, the growth of the UiO-66 framework on the coated nanoparticles was unsuccessful; further optimisation of parameters such as synthesis temperature, reaction time, and modulator choice are required to prevent oxidation of the core while promoting the growth of the metal-organic framework.

Palabras clave: Magnetite nanoparticles, l-cysteine, UiO-66, magnetic hyperthermia, cancer, nanomedicine.

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Table of content

Acknowledgements

Chapter 1. Introduction

Chapter 2. Justification

Chapter 3. Theoretical Framework

Chapter 4. Experimental Section

Chapter 5. Results and Discussion

Chapter 6. Conclusions

References

Appendix 1. Trial 1

Appendix 2. Trial 2

Appendix 3. Trial 3

Appendix 4. Trial 4

Appendix 5. Trial 5

Appendix 6. RME for UiO-66/Fe3O4@L-cys trials

Appendix 8. Trial 2 Fe3O4@L-cys nanoparticles

Appendix 9. Trial 3 Fe3O4@L-cys nanoparticles

Appendix 10. Trial 4 Fe3O4@L-cys nanoparticles

Appendix 11. Trial 5 Fe3O4@L-cys nanoparticles

Appendix 12. UiO-66

Appendix 13. UiO-66/Fe3O4@L-cys trials 1-5

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Reyes Miranda, M. 2024. Metal-Organic Frameworks Coated on Magnetic Nanoparticles for Cancer Therapy. Tesis Licenciatura. Nanotecnología e Ingeniería Molecular. Departamento de Ciencias Químico Biológicas, Escuela de Ciencias, Universidad de las Américas Puebla. Diciembre. Derechos Reservados © 2024.