Tesis profesional presentada por
Miembro del Programa de Honores. Licenciatura en Nanotecnología e Ingeniería Molecular. Departamento de Ciencias Químico Biológicas. Escuela de Ciencias, Universidad de las Américas Puebla.
Jurado Calificador
Director: Dr. Miguel Angel Méndez
Rojas
Presidente: Dra. Mónica Cerro
López
Secretario: Dr. Ricardo Navarro Amador
Vocal: Dr. Felipe Córdova Lozano
Cholula, Puebla, México a 2 de diciembre de 2024.
A system of Ni1-xZnxFe2O4 nanoparticles with varying Zn2+ content (x=0, 0.25, 0.5, 0.75) was synthesized via chemical co-precipitation and sintered at 1000°C to enhance magnetic properties. The nanoparticles were extensively characterized (XRD, SEM, EDX, Raman, FTIR, and magnetic hyperthermia studies), revealing crystalline sizes below 20 nm, except for x=0.25, which exhibited sizes of 25-28 nm. Secondary phases (hematite and nickel oxide) were detected in the x=0.25 sample, and while these were removed through acidic treatment to improve crystallinity, the ferrites containing impurities prior to the acidic treatment showed the best hyperthermia performance. This behavior is attributed to the presence of magnetic oxides, as confirmed by XRD analysis. Acid treatment increased nanoparticle stability, corroborated by DLS studies, and the x=0.75 sample demonstrated the best magnetic hyperthermia performance after treatment, likely due to lattice parameter rearrangements. Homogeneous nanofibers were fabricated via electrospinning, using the synthesized nanoparticles coupled with chitosan and PVA. Various component concentrations were tested, with the most suitable being 2.75% chitosan and 10% PVA. Additionally, initial efforts were made to create core-shell nanofibers using the same chitosan/PVA/ferrite nanoparticle core with a polymeric polycaprolactone shell. However, methodological constraints prevented their complete formation, and these challenges will be addressed in future research.
Keywords: Magnetic nanoparticles; Nanofibers; Magnetic Hyperthermia; Electrospinning; Nanomedicine.
Acknowledgements
Chapter 1. Introduction
Chapter 2. Justification
Chapter 3. Objectives
Chapter 4. Theoretical background
Chapter 5. Methodology
Chapter 6. Results and discussion
Chapter 7. Conclusions and Recommendations
References
Annex 1. Calculus of magnetic nanoparticles synthesis
González Hidalgo, R. 2024. Synthesis and characterization of Ni1-xZnxFe2O4-chitosan-PVA nanofibers and evaluation of their performance as a magnetic hyperthermia agent. Tesis Licenciatura. Nanotecnología e Ingeniería Molecular. Departamento de Ciencias Químico Biológicas, Escuela de Ciencias, Universidad de las Américas Puebla. Diciembre. Derechos Reservados © 2024.